ITGA5 - integrin subunit alpha 5 Gene

Also Known as FNRA; CD49e; VLA-5; VLA5A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3678

About ITGA5

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,395,261-54,419,266 (from NCBI)

This gene has 13 transcripts (splice variants), 268 orthologues and 17 paralogues. Broad expression in appendix (RPKM 85.6), urinary bladder (RPKM 54.1) and 19 other tissues.

Summary

The product of this gene belongs to the Integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This Integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung Cancer patients. Note that the Integrin alpha 5 and Integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

ITGA5 Products (1)

mRNA	Protein	Name
NM_002205.5	NP_002196.4	integrin alpha-5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	33962943	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12695522	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CD40 signaling pathway	IDA IDA: Inferred from direct assay	31331973	GOA
involved in cell adhesion	IDA IDA: Inferred from direct assay	19703720	GOA
involved in cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	12807887	GOA
involved in cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	19933311	GOA
involved in endodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	23154389	GOA
involved in heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	20563599	GOA
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	31331973	GOA
involved in negative regulation of anoikis	IMP IMP: Inferred from mutant phenotype	15006356	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	10022831	GOA
involved in positive regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	19460962	GOA
involved in wound healing, spreading of epidermal cells	IEP IEP: Inferred from expression pattern	14970227	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	17158881	GOA
colocalizes with cell-cell junction	IDA IDA: Inferred from direct assay	14970227	GOA
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	14970227	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	17158881	GOA
part of integrin alpha5-beta1 complex	IDA IDA: Inferred from direct assay	31331973	GOA
part of integrin alpha5-beta1 complex	IPI IPI: Inferred from physical interaction	22451694	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19141530	GOA
colocalizes with ruffle membrane	IDA IDA: Inferred from direct assay	14970227	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGA5 Protein Structure

FG-GAP

Integrin_alpha2

0
200
400
600
800
1000
1049 a.a.

Protein Preferred Names	Protein Names
integrin alpha-5	CD49 antigen-like family member E

ITGA5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	ITGA5	P08648	Nrp1	Mus musculus	P97333	FRET	19175293
Cross	ITGA5	P08648	Nrp1	Mus musculus	P97333	Anti Tag CoIP	19175293
Intra	ITGA5	P08648	ENG	Homo sapiens	P17813	IF	22940691
Intra	ITGA5	P08648	ENG	Homo sapiens	P17813	Anti Bait CoIP	22940691
Intra	ITGA5	P08648	SHARPIN	Homo sapiens	Q9H0F6	Anti Bait CoIP	21947080
Intra	ITGA5	P08648	SHARPIN	Homo sapiens	Q9H0F6	Anti Tag CoIP	21947080
Intra	ITGA5	P08648	ITGB1	Homo sapiens	P05556	Anti Tag CoIP	33961781
Intra	ITGA5	P08648	ITGB1	Homo sapiens	P05556	ELISA	16099422
Intra	ITGA5	P08648	ITGB1	Homo sapiens	P05556	Anti Bait CoIP	21947080
Intra	ITGA5	P08648	ITGB1	Homo sapiens	P05556	ELISA	22451694
Intra	ITGA5	P08648	ITGB1	Homo sapiens	P05556	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ITGA5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72533	ITGA5 Protein, Human (HEK293, His)	P08648 (F42-Y995)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73872	Integrin alpha 5 beta 1 Protein, Human (HEK293, Flag-His)	P08648 (F42-Y995) & P05556-1 (Q21-D728)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77718	Integrin alpha 5 beta 1 Protein, Human (HEK293, His-Avi)	P08648 (F42-Y995)&P05556-1 (Q21-D728)	≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

ITGA5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80416	Integrin alpha 5 Antibody (YA339)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
HY-P85230	Integrin α5 Antibody (YA4922)	WB; IHC-P; IHC-F; IF-Tissue; IP	Human, Mouse, Rat
HY-P85439	Integrin α5 Antibody (YA5131)	WB, FC	Human, Mouse, Rat, Bovine

Related Diseases

Diseases	Alias
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Colorectal Cancer, Hereditary Nonpolyposis, Type 8	HNPCC8 Hereditary Nonpolyposis Colorectal Cancer Type 8 Hereditary Non-Polyposis Colorectal Cancer 8 Cancer, Colorectal, Nonpolyposis, Hereditary, Type 8
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Kaposi'S Sarcoma-Associated Herpesvirus Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Prolapse Of Urethra	Urethrocele
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Intrahepatic Bile Duct Adenoma	Adenoma Of Intrahepatic Bile Duct Adenoma Of The Intrahepatic Bile Duct
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06952	ITGA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16901	Itga5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23343	Itga5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ITGA5	VGNC	VGNC:42127
Macaca mulatta	ITGA5	VGNC	VGNC:73779
Bos taurus	ITGA5	VGNC	VGNC:30317
Rattus norvegicus	ITGA5	RGD	RGD:2925
Felis catus	ITGA5	VGNC	VGNC:67843
Mus musculus	ITGA5	MGD	MGI:96604
Others	ITGA5	NCBI